PharmacyCodes



Acido meclofenamico [INN-Spanish] en es it fr

Acido meclofenamico [INN-Spanish] Brand names, Acido meclofenamico [INN-Spanish] Analogs

Acido meclofenamico [INN-Spanish] Brand Names Mixture

  • No information avaliable

Acido meclofenamico [INN-Spanish] Chemical_Formula

C5H4N4S

Acido meclofenamico [INN-Spanish] RX_link

http://www.rxlist.com/cgi/generic2/mercaptopurine.htm

Acido meclofenamico [INN-Spanish] fda sheet

Acido_meclofenamico_[INN-Spanish] FDA

Acido meclofenamico [INN-Spanish] msds (material safety sheet)

Acido_meclofenamico_[INN-Spanish] MSDS

Acido meclofenamico [INN-Spanish] Synthesis Reference

No information avaliable

Acido meclofenamico [INN-Spanish] Molecular Weight

152.178 g/mol

Acido meclofenamico [INN-Spanish] Melting Point

313 oC

Acido meclofenamico [INN-Spanish] H2O Solubility

6.85 mg/mL

Acido meclofenamico [INN-Spanish] State

Solid

Acido meclofenamico [INN-Spanish] LogP

0.335

Acido meclofenamico [INN-Spanish] Dosage Forms

Tablet (50-mg, scored) for oral administration

Acido meclofenamico [INN-Spanish] Indication

For remission induction and maintenance therapy of acute lymphatic leukemia.

Acido meclofenamico [INN-Spanish] Pharmacology

Mercaptopurine is one of a large series of purine analogues which interfere with nucleic acid biosynthesis and has been found active against human leukemias. It is an analogue of the purine bases adenine and hypoxanthine. It is not known exactly which of any one or more of the biochemical effects of mercaptopurine and its metabolites are directly or predominantly responsible for cell death.

Acido meclofenamico [INN-Spanish] Absorption

Clinical studies have shown that the absorption of an oral dose of mercaptopurine in humans is incomplete and variable, averaging approximately 50% of the administered dose. The factors influencing absorption are unknown.

Acido meclofenamico [INN-Spanish] side effects and Toxicity

Signs and symptoms of overdosage may be immediate such as anorexia, nausea, vomiting, and diarrhea; or delayed such as myelosuppression, liver dysfunction, and gastroenteritis. The oral LD50 of mercaptopurine was determined to be 480 mg/kg in the mouse and 425 mg/kg in the rat.

Acido meclofenamico [INN-Spanish] Patient Information

No information avaliable

Acido meclofenamico [INN-Spanish] Organisms Affected

Humans and other mammals